[Blind-sysadmins] Sharepoint 2013 and accessibility with all screen readers

Hello all, I've got a few questions here. I and a couple of friends of mine use Sharepoint 2013 for document management and general communications on the front page of the site. I was given the honor of setting up SP, but I ended up having to give the task to my more sighted friend because too much of it was either inaccessible or viewable but nonactive with NVDA. (and I do not know how to use the PS modules for SP.) Even parts of the site itself seem inaccessible with NVDA or any other screen reader for that matter. What are your suggestions for using SP with screen readers? Thanks all.